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Leishmanicidal Activity of Betulin Derivatives in Leishmania amazonensis; Effect on Plasma and Mitochondrial Membrane Potential, and Macrophage Nitric Oxide and Superoxide Production.

Wilmer AlcazarSami AlakurttiMaritza Padrón-NievesMaija Liisa TuononenNoris RodríguezJari T Yli-KauhaluomaAlicia Ponte-Sucre
Published in: Microorganisms (2021)
Our results suggest that due to their efficacy and selectivity against intracellular parasites and the potential mechanisms underlying their leishmanicidal effect, the compounds 18 and 22 could be used as tools for designing new chemotherapies against leishmaniasis.
Keyphrases
  • nitric oxide
  • hydrogen peroxide
  • oxidative stress
  • adipose tissue
  • human health
  • reactive oxygen species
  • climate change
  • structure activity relationship