Altered endotoxin responsiveness in healthy children with Down syndrome.
Dean HuggardFiona McGraneNiamh LaganEdna RocheJoanne BalfeTimothy Ronan LeahyOrla FranklinAna MorenoAshanty M MeloDerek G DohertyEleanor J MolloyPublished in: BMC immunology (2018)
Melatonin could represent a useful clinical adjunct in the treatment of sepsis as an immunomodulator. Children with DS had increased LPS responses which may contribute to the more adverse outcomes seen in sepsis.