Copy-Number Alteration Burden Differentially Impacts Immune Profiles and Molecular Features of Hepatocellular Carcinoma.

Laia BassaganyasRoser PinyolRoger Esteban-FabróLaura TorrensSara TorrecillaCatherine E Willoughby Sebastià Franch-ExpósitoMaria Vila-CasadesúsItziar SalaverriaRobert MontalVincenzo MazzaferroJordi CampsDaniela SiaJosep M Llovet

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

HCCs with high chromosomal instability exhibit features of immune exclusion, whereas tumors displaying low burdens of broad CNAs present an immune active profile. These CNA scores can be tested to predict response to immunotherapies.

Keyphrases

copy number
mitochondrial dna
genome wide
dna methylation
gene expression