Gene expression identifies patients who develop inflammatory arthritis in a clinically suspect arthralgia cohort.

Ellis NiemantsverdrietErik B van den AkkerDebbie M BoetersSusan J F van den EedenAnnemieke GelukAnnette H M van der Helm-van Mil

Published in: Arthritis research & therapy (2020)

IL-7R and IGF-1 were differentially expressed between CSA patients who did or did not progress to IA, independent from regularly used predictors. These biomarkers may become helpful in prognostication of CSA patients. Furthermore, because both genes are associated with T cell functioning, T cell dysregulation may mediate progression from arthralgia to arthritis.

Keyphrases

gene expression
end stage renal disease
rheumatoid arthritis
genome wide
ejection fraction
chronic kidney disease
dna methylation
newly diagnosed
prognostic factors
transcription factor
bioinformatics analysis