The functional role of CST1 and CCL26 in asthma development.

Angela HoyerSandip ChakrabortyIngrid LilienthalJon R KonradsenShintaro KatayamaCilla Söderhäll

Published in: Immunity, inflammation and disease (2024)

Our results indicate that an overexpression of CST1 and CCL26 cause a downregulation of interferon related genes and inflammatory proteins. It might cause a higher disease susceptibility, mainly for allergic asthma, as CCL26 is an agonist for CCR-3-carrying cells, such as eosinophils and Th2 lymphocytes, mostly active in allergic asthma.

Keyphrases

allergic rhinitis
chronic obstructive pulmonary disease
lung function
liver fibrosis
liver injury
induced apoptosis
cell proliferation
dendritic cells
drug induced
signaling pathway
oxidative stress
cell cycle arrest
cystic fibrosis
regulatory t cells
peripheral blood
endoplasmic reticulum stress