Systematic evaluation of nine monogenic autoinflammatory diseases reveals common and disease-specific correlations with allergy-associated features.
Daniella Muallem SchwartzMoses M KitakuleBrian Lp DizonCristhian Gutierrez-HuertaSarah A BlackstoneAarohan M BurmaAran SonNatalie DeuitchSofia RosenzweigHirsh KomarowDeborah L StoneAnne JonesMichele NehrebeckyPatrycja HoffmannTina RomeoAdriana Almeida de JesusSara AlehashemiMegha GargSofia TorreggianiGina A Montealegre SanchezKatelin HonerGema Souto AdevaKaryl S BarronIvona AksentijevichAmanda K OmbrelloRaphaela Goldbach ManskyDaniel L KastnerJoshua D MilnerPamela Frischmeyer-GuerrerioPublished in: Annals of the rheumatic diseases (2021)
CAPS is characterised by an enhanced Type 2 signature, whereas FMF and CANDLE are associated with reduced Type 2 responses. DADA2 is associated with reduced Type 2 responses but a high rate of physician-diagnosed allergy. Therefore, NLRP3-driven autoinflammation may promote Type 2 immunity, whereas AID like DADA2 may manifest clinical phenotypes that masquerade as allergic disorders. Further investigations are needed to determine the contribution of autoinflammation to allergic clinical and immunological phenotypes, to improve the treatment of patients with AID.