Acyltransferase skinny hedgehog regulates TGFβ-dependent fibroblast activation in SSc.
Ruifang LiangRosebeth KagwiriaAriella ZehenderClara DeesChristina BergmannAndreas RammingDorota KrasowskaMałgorzata Michalska-JakubusAlexander KreuterMax E KranerLarissa Valor-MéndezJörg H W DistlerPublished in: Annals of the rheumatic diseases (2019)
HHAT is regulated in SSc in a TGFβ-dependent manner and in turn stimulates TGFβ-induced long-range hedgehog signalling to promote fibroblast activation and tissue fibrosis. Targeting of HHAT might be a novel approach to more selectively interfere with the profibrotic effects of long-range hedgehog signalling.