Epigenetic Biomarkers of Transition from Metabolically Healthy Obesity to Metabolically Unhealthy Obesity Phenotype: A Prospective Study.

Carolina Gutierrez-RepisoTeresa María Linares-PinedaAndres Gonzalez-JimenezFrancisca Aguilar-LinerosSergio ValdesFederico SoriguerGemma Rojo-MartínezFrancisco J TinahonesSonsoles Morcillo

Published in: International journal of molecular sciences (2021)

DNA methylation status is associated with the stability/worsening of MHO phenotype. Two potential biomarkers of the transition to an unhealthy state were identified and deserve further investigation (cg20707527 and cg11445109). Moreover, the described differences in methylation could alter immune system-related pathways, highlighting these pathways as therapeutic targets to prevent metabolic deterioration in MHO patients.

Keyphrases

dna methylation
insulin resistance
metabolic syndrome
end stage renal disease
weight loss
type diabetes
genome wide
gene expression
ejection fraction
newly diagnosed
high fat diet induced
peritoneal dialysis
prognostic factors
adipose tissue
patient reported outcomes
copy number