Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice.
Zachery KonevalKevin M KnoxAli MemonDannielle K ZierathH Steve WhiteMelissa Barker-HaliskiPublished in: Epilepsia (2020)
Altogether, this study provides strain-related information to differentiate investigational agents from ASD standards-of-care in commonly employed preclinical discovery models and describes a novel kindled seizure model to further explore the mechanisms of drug-resistant epilepsy.
Keyphrases
- drug resistant
- drug discovery
- multidrug resistant
- acinetobacter baumannii
- temporal lobe epilepsy
- healthcare
- autism spectrum disorder
- small molecule
- palliative care
- open label
- quality improvement
- attention deficit hyperactivity disorder
- emergency department
- metabolic syndrome
- high throughput
- stem cells
- drug induced
- type diabetes
- clinical trial
- cell therapy
- high fat diet induced
- mesenchymal stem cells
- affordable care act
- single cell
- health insurance
- study protocol
- electronic health record