TLR5 Activation Exacerbates Airway Inflammation in Asthma.

G S WhiteheadS HussainR FanninC S TrempusC L InnesS H SchurmanD N CookStavros Garantziotis

Published in: Lung (2020)

Together, our results reveal a novel genetic protective factor (TLR5 deficiency) and a novel environmental pollutant (microbial flagellin) that influence asthma severity. (Clinical trials NCT01688986 and NCT01087307).

Keyphrases

chronic obstructive pulmonary disease
toll like receptor
clinical trial
lung function
inflammatory response
genome wide
immune response
allergic rhinitis
microbial community
single cell
cystic fibrosis
air pollution
phase ii
human health
risk assessment
life cycle
study protocol