Entorhinal vessel density correlates with phosphorylated tau and TDP-43 pathology.
Josué Llamas RodríguezAndré J W van der KouweJan OltmerEmma RosenblumNathaniel MercaldoBruce FischlMichael MarshallMatthew P FroschJean C AugustinackPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Vessel density correlates with phosphorylated tau (p-tau) burden in entorhinal and perirhinal cortices. Perirhinal area 35 and posterior entorhinal cortex showed greatest p-tau burden but also the highest vessel density in the preclinical phase of Alzheimer's disease. We combined an ex vivo magnetic resonance imaging model and histopathology to demonstrate the 3D reconstruction of intracortical vessels and its spatial relationship to the pathology.