Host genetic liability for severe COVID-19 overlaps with alcohol drinking behavior and diabetic outcomes in over 1 million participants.

Frank R WendtAntonella De LilloGita A PathakFlavio De AngelisRenato Polimanti

Published in: medRxiv : the preprint server for health sciences (2020)

To distinguish correlation from causation, we performed in-silico analyses of three COVID-19 outcomes (N>1,000,000). We show genetic correlation and putative causality with depressive symptoms, metformin use, and alcohol use. COVID-19 risk loci associated with several hematologic biomarkers. Comprehensive findings inform genetic contributions to COVID-19 epidemiology, molecular mechanisms, and risk factors.

Keyphrases

coronavirus disease
sars cov
risk factors
genome wide
depressive symptoms
respiratory syndrome coronavirus
type diabetes
copy number
emergency department
metabolic syndrome
alcohol consumption
sleep quality
weight loss
insulin resistance
adipose tissue
wound healing
genome wide association study