An ancestry-based approach for detecting interactions.
Danny S ParkItamar EskinEun Yong KangEric R GamazonCeleste EngChristopher R GignouxJoshua M GalanterEsteban BurchardChun J YeHugues AschardEleazar EskinEran HalperinNoah ZaitlenPublished in: Genetic epidemiology (2017)
We show that genetic ancestry can be a useful proxy for unknown and unmeasured covariates in the search for interaction effects. These results have important implications for our understanding of the genetic architecture of complex traits.