Computing of Low Shear Stress-Driven Endothelial Gene Network Involved in Early Stages of Atherosclerotic Process.

Federico Vozzi Jonica Campolo Lorena Cozzi Gianfranco Politano Stefano Di CarloMichela RialClaudio DomeniciOberdan Parodi

Published in: BioMed research international (2018)

The significant modulation of these genes at low shear stress and their close relationships through transcription factors and microRNAs suggest that all may promote an initial inflamed endothelial cell phenotype, favoring the atherosclerotic disease.

Keyphrases

genome wide identification
endothelial cells
transcription factor
genome wide
genome wide analysis
copy number
high glucose
dna methylation
dna binding
bioinformatics analysis
gene expression
vascular endothelial growth factor