Targeted delivery of protein arginine deiminase-4 inhibitors to limit arterial intimal NETosis and preserve endothelial integrity.

Roberto Molinaro Mikyung Yu Grasiele SausenColette A BichselClaudia Corbo Eduardo J Folco Gha Young LeeYuan LiuYevgenia TesmenitskyEugenia ShvartzGalina K Sukhova Frederik KlossKevin J CroceOmid C FarokhzadJinjun ShiPeter Libby

Published in: Cardiovascular research (2022)

NPs directed to Col IV show selective uptake and delivery of their payload to experimentally eroded regions, illustrating their translational potential. Our results further support the role of PAD4 and NETs in superficial erosion.

Keyphrases

amino acid
nitric oxide
endothelial cells
protein protein
binding protein
risk assessment
small molecule
oxide nanoparticles
climate change