Modified exosomal SIRPα variants alleviate white matter injury after intracerebral hemorrhage via microglia/macrophages.

Xinjie GaoHeng YangWeiping XiaoJiabin SuYuwen ZhangHe WangWei NiYuxiang Gu

Published in: Biomaterials research (2022)

Our studies revealed that SIRPα-v Exos could accelerate the clearance of hematoma and ameliorate secondary white matter injury after ICH through regulation of microglia/macrophages. SIRPα-v Exos may become a promising treatment for ICH in clinical practice.

Keyphrases

white matter
clinical practice
multiple sclerosis
inflammatory response
neuropathic pain
copy number
spinal cord
spinal cord injury
dna methylation
combination therapy
genome wide
replacement therapy