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Detection of SARS-CoV-2 infection by saliva and nasopharyngeal sampling in frontline healthcare workers: An observational cohort study.

Naomi F WalkerRachel L ByrneAshleigh HowardElissavet NikolaouMadlen FarrarSharon GlynnKaterina S CheliotisAna Isabel Cubas-AtienzarKelly DaviesJesús ReinéZalina Rashid-GardnerEsther L GermanCarla SolórzanoTess BlandamerLisa HitchinsChristopher MyerscoughBradford D GessnerElizabeth BegierAndrea M CollinsMike BeadsworthStacy ToddHelen HillCatherine F HoulihanEleni NastouliEmily R AdamsElena MitsiDaniela M Ferreiranull null
Published in: PloS one (2023)
HCW are a potential source of SARS-CoV-2 transmission in hospitals and symptom screening will identify the minority of infections. Without routine asymptomatic SARS-CoV-2 screening, it is likely that HCW with SARS-CoV-2 infection would continue to attend work. Saliva, in addition to OP/NP swab testing, facilitated ascertainment of symptomatic and asymptomatic SARS-CoV-2 infections. Combined saliva and OP/NP swab sampling would improve detection of SARS-CoV-2 for surveillance and is recommended for a high sensitivity strategy.
Keyphrases
  • sars cov
  • respiratory syndrome coronavirus
  • healthcare
  • public health
  • loop mediated isothermal amplification
  • coronavirus disease
  • real time pcr
  • clinical practice
  • label free
  • patient reported