Long noncoding RNAs in pancreas cancer: from biomarkers to therapeutic targets.
Guzel Tanoglu EsraSeyfure AdigüzelAlpaslan TanoğluZehra Betül AydinGülizar HocaoğluSamet EbinçPublished in: Turkish journal of medical sciences (2023)
Long noncoding RNAs (lncRNAs) are noncoding RNA molecules with a heterogeneous structure consisting of 200 or more nucleotides. Because these noncoding RNAs are transcribed by RNA polymerase II, they have properties similar to messenger RNA (mRNA). Contrary to popular belief, the term "ncRNA" originated before the discovery of microRNAs. LncRNA genes are more numerous than protein-coding genes. They are the focus of current molecular research because of their pivotal roles in cancer-related processes such as cell proliferation, differentiation, and migration. The incidence of pancreatic cancer (PC) is increasing around the world and research on the molecular aspects of PC are growing. In this review, it is aimed to provide critical information about lncRNAs in PC, including the biological and oncological behaviors of lncRNAs in PC and their potential application in therapeutic strategies and as diagnostic tumor markers.
Keyphrases
- genome wide identification
- genome wide analysis
- cell proliferation
- genome wide
- network analysis
- small molecule
- transcription factor
- risk factors
- binding protein
- prostate cancer
- long non coding rna
- squamous cell carcinoma
- cell cycle
- single molecule
- risk assessment
- dna methylation
- health information
- social media
- nucleic acid
- gestational age
- robot assisted
- single cell
- lymph node metastasis
- preterm birth