Squalene Epoxidase Metabolic Dependency Is a Targetable Vulnerability in Castration-Resistant Prostate Cancer.

Xun ShangguanZehua MaMinghao YuJie Ding Wei XueJun Qi

Published in: Cancer research (2022)

This study reveals PTEN and p53 deficiency confers a dependence on SQLE-mediated cholesterol metabolism, providing insights for new therapeutic strategies for treating castration-resistant prostate cancer.

Keyphrases

climate change
cell proliferation
pi k akt
low density lipoprotein