C5aR1 antagonism suppresses inflammatory glial gene expression and alters cellular signaling in an aggressive Alzheimer's model.

Nicole D Schartz Heidi Yahan Liang Klebea Carvalho Shu-Hui Chu Adrian Mendoza-Arvilla Tiffany J Petrisko Angela Gomez-Arboledas Ali Mortazavi Andrea J Tenner

Published in: bioRxiv : the preprint server for biology (2023)

Pharmacologic inhibition of C5aR1 suppresses disease-enhancing processes and promotes disease mitigating pathways in an aggressive model of Alzheimer's disease.

Keyphrases

gene expression
signaling pathway
cognitive decline
dna methylation
oxidative stress
spinal cord
neuropathic pain
spinal cord injury
mild cognitive impairment