Urinary steroid profiling in women hints at a diagnostic signature of the polycystic ovary syndrome: A pilot study considering neglected steroid metabolites.

Nasser A DhayatNesa MartiZahraa KollmannAmineh TroendleLia BallyGeneviève EscherMichael GrösslDaniel AckermannBelen PonteMenno PruijmMichael MüllerBruno VogtMartin H BirkhäuserMurielle BochudChrista E Flucknull null

Published in: PloS one (2018)

PCOS shows a specific 24h urinary steroid profile, if neglected metabolites are included in the analysis and non-conventional data analysis applied. PCOS does not share a profile with hyperandrogenic forms of congenital adrenal hyperplasias due to single steroid enzyme deficiencies. Thus PCOS diagnosis by exclusion may no longer be warranted. Whether these findings also apply to spot urine and serum, remains to be tested as a next step towards routine clinical applicability.

Keyphrases

polycystic ovary syndrome
data analysis
insulin resistance
ms ms
metabolic syndrome
skeletal muscle
type diabetes
adipose tissue
pregnant women