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Multidrug Cancer Therapy in Metastatic Castrate-Resistant Prostate Cancer: An Evolution-Based Strategy.

Jeffrey B WestMina N DinhJoel S BrownJingsong ZhangAlexander A R A AndersonRobert A Gatenby
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Mathematical models can integrate evolutionary dynamics into multidrug cancer clinical trials. This has the potential to improve outcomes and to develop clinical trials in which these mathematical models are also used to estimate the mechanism(s) of treatment failure and explore alternative strategies to improve outcomes in future trials.
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