Evaluation of the Efficacy of Stem Cell Therapy in Ovariectomized Osteoporotic Rats Based on Micro-CT and Dual-Energy X-Ray Absorptiometry: A Systematic Review and Meta-Analysis.
Zhencheng XiongPing YiJialiang LinShengfeng QiuLi ShuChi ZhangPublished in: Stem cells international (2021)
Stem cell therapy may increase bone strength, bone volume, and the number of trabeculae in OVX osteoporotic rats. The results of this meta-analysis showed the potential therapeutic effect of stem cell transplantation in OVX osteoporotic rats, bringing new therapeutic ideas and directions to the clinical treatment of osteoporosis. Due to the limited number and quality of studies related to some outcomes, more high-quality RCTs are still needed in the future to complement the existing findings.
Keyphrases
- dual energy
- bone mineral density
- cell therapy
- stem cell transplantation
- computed tomography
- postmenopausal women
- stem cells
- image quality
- body composition
- systematic review
- high dose
- contrast enhanced
- positron emission tomography
- skeletal muscle
- adipose tissue
- insulin resistance
- quality improvement
- weight loss
- pet ct
- drug induced
- bone regeneration