Tissue Interleukin-33: A Novel Potential Regulator of Innate Immunity and Biomarker of Disease Severity in Chronic Rhinosinusitis with Nasal Polyps.
Ioana Maria Porfire IrimiaIoana Berindan NeagoeLivia BudisanDaniel-Corneliu LeucutaAnda GataAurelian Costin MinoiuBogdan Alexandru GeorgescuBogdan Florin CovaliuSilviu AlbuPublished in: Journal of clinical medicine (2023)
Our research analyzed the levels of polyp IL-33, relative to blood eosinophilia, overall disease severity score, and osteitis severity, in patients with CRSwNP. These variables are prognostic predictors for poor outcomes and recalcitrant disease. Considering the importance of bone involvement in CRSwNP, this research aims to provide a better insight into the correlations of osteitis with clinical and biological factors.