Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway.

Xufen ZhengYuxiang LuoYangjie XiongXiaoxiao LiuChunling ZengXiaojing LuXiaofang WangYumei Cheng Simin Wang Haoqi LanKai WangZhonghui WengWenbo BiXinxin GanXiaona JiaLinhui WangYuexiang Wang

Published in: Journal for immunotherapy of cancer (2023)

These findings provide novel insights into the biology of SETD2 inactivation regulation and reveal a new potential therapeutic biomarker for ICIs immunotherapy in various refractory cancers.

Keyphrases

single cell
cell therapy
cell proliferation

genome wide
induced apoptosis
stem cells

gene expression
oxidative stress

signaling pathway
bone marrow