Recurrence in acromegaly: two tertiary centers experience and review of the literature.
A CremaschiE SalaE LavezziG CarosiG Del SindacoA MangoneR MungariA PagnanoR IndirliE FerranteG MazziottiM LocatelliG LasioM ArosioA G LaniaG MantovaniPublished in: Journal of endocrinological investigation (2024)
In the literature, recurrence rates range widely, from 0 to 18%. In our series, recurrence occurred in 3.7% of patients, and in fewer than 1%, recurrence occurred with elevation of both IGF-1 and the GH nadir. More frequently (25%), recurrence came in the form of incomplete normalization of either IGF-1 or GH after surgery.