Plasma radio-metabolite analysis of PET tracers for dynamic PET imaging: TLC and autoradiography.

Fiona LiJustin W HicksLihai YuLise DesjardinLaura MorrisonJennifer HadwayTing-Yim Lee

Published in: EJNMMI research (2020)

TLC coupled with autoradiography is a good alternative to high-performance liquid chromatography for radio-metabolite correction. The advantages of requiring only small blood samples (~ 100 μL) and of analyzing multiple samples simultaneously, make the method suitable for individual dynamic PET studies.

Keyphrases

pet imaging
high performance liquid chromatography
positron emission tomography
tandem mass spectrometry
mass spectrometry
simultaneous determination
solid phase extraction
computed tomography
pet ct
liquid chromatography
ms ms
high resolution
case control