Current Use of and Trends in Hematopoietic Cell Transplantation in the United States.
Anita D'SouzaCaitrin FrethamStephanie J LeeMukta AroraJanet BrunnerSaurabh ChhabraSteven DevineMary EapenMehdi HamadaniParameswaran HariMarcelo C PasquiniWaleska PerezRachel A PhelanMarcie L RichesJ Douglas RizzoWael SaberBronwen E ShawStephen R SpellmanPatricia SteinertDaniel J WeisdorfMary M HorowitzPublished in: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation (2020)
Hematopoietic cell transplantation (HCT) is a well-established treatment to control and/or cure many malignant and nonmalignant diseases involving the hematopoietic system and some solid tumors. We report information about HCT procedures performed in the United States in 2018 and analyze trends and outcomes of HCT as reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). Overall, compared with 2017, the number of allogeneic HCTs performed in the United States increased by 1%, and the number of autologous HCTs decreased by 5%. Key findings are fewer autologous HCTs performed for non-Hodgkin lymphoma and increasing numbers of haploidentical HCTs, nearly all of which use post-transplantation cyclophosphamide for graft-versus-host disease prophylaxis. There is a continuing increase in HCT in adults age >70 years, particularly for acute myelogenous leukemia and myelodysplastic syndromes. Survival rates by disease, disease stage, donor type, and age are presented. This report, prepared annually by the CIBMTR, provides a snapshot of current transplant activity in the United States.
Keyphrases
- bone marrow
- cell cycle arrest
- stem cell transplantation
- cell therapy
- mesenchymal stem cells
- liver failure
- cell death
- low dose
- cell proliferation
- respiratory failure
- platelet rich plasma
- health information
- peripheral blood
- stem cells
- healthcare
- adipose tissue
- aortic dissection
- social media
- glycemic control
- smoking cessation
- metabolic syndrome