Pivotal role of phosphodiesterase 10A in the integration of dopamine signals in mice striatal D1 and D2 medium-sized spiny neurones.
Élia MotaSégolène BompierreDahdjim BetolngarLiliana R V CastroPierre VincentPublished in: British journal of pharmacology (2021)
In both MSN types, PDE10A inhibition blunts the responsiveness to dopamine, whereas PDE2A or PDE4 inhibition reinforces dopamine action.