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HER2-targeted antibody-drug conjugates for breast cancer: ancestry and dose adjustment for thrombocytopenia.

Michael RainoneCarolyn E BehrendtSaro KasparianTina NguyenMina S SedrakSayeh LavasaniDaphne B StewartYuan YuanJoanne E MortimerJames R WaismanNiki PatelVinod A Pullarkat
Published in: Breast cancer (Tokyo, Japan) (2023)
The association between Asian ancestry and thrombocytopenia on HER2-targeted therapy is independent of age, metastatic disease, drug, and history of similar toxicity. This association may have a genetic basis linked to Chinese ancestry.
Keyphrases
  • genome wide association study
  • cancer therapy
  • squamous cell carcinoma
  • small cell lung cancer
  • oxidative stress
  • genome wide
  • drug delivery
  • emergency department
  • dna methylation
  • young adults