HER2-targeted antibody-drug conjugates for breast cancer: ancestry and dose adjustment for thrombocytopenia.
Michael RainoneCarolyn E BehrendtSaro KasparianTina NguyenMina S SedrakSayeh LavasaniDaphne B StewartYuan YuanJoanne E MortimerJames R WaismanNiki PatelVinod A PullarkatPublished in: Breast cancer (Tokyo, Japan) (2023)
The association between Asian ancestry and thrombocytopenia on HER2-targeted therapy is independent of age, metastatic disease, drug, and history of similar toxicity. This association may have a genetic basis linked to Chinese ancestry.