HER2-targeted antibody-drug conjugates for breast cancer: ancestry and dose adjustment for thrombocytopenia.

Michael RainoneCarolyn E BehrendtSaro KasparianTina NguyenMina S SedrakSayeh LavasaniDaphne B StewartYuan YuanJoanne E MortimerJames R WaismanNiki PatelVinod A Pullarkat

Published in: Breast cancer (Tokyo, Japan) (2023)

The association between Asian ancestry and thrombocytopenia on HER2-targeted therapy is independent of age, metastatic disease, drug, and history of similar toxicity. This association may have a genetic basis linked to Chinese ancestry.

Keyphrases

genome wide association study
cancer therapy
squamous cell carcinoma
small cell lung cancer
oxidative stress
genome wide
drug delivery
emergency department
dna methylation
young adults