Multiplexed LC-MS/MS quantification of salivary RNA modifications in periodontitis.
Margaux VignonAmandine BastideAurore AttinaAlexandre DavidPhilippe BousquetValérie OrtiJérôme VialaretSylvain LehmannDominique DevilleDe PeriereChristophe HirtzPublished in: Journal of periodontal research (2023)
The high specificity and sensitivity of MS allowed the detection and quantification of multiple nucleosides from RNA and free nucleosides in saliva. Some ribonucleosides appear to be promising biomarkers of periodontitis. Our analytic pipeline opens new perspectives for diagnostic periodontitis biomarkers.