Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel model.
Jee-Wei Emily ChenJan LumibaoSarah LearyJann N SarkariaAndrew J SteelmanH Rex GaskinsBrendan A C HarleyPublished in: Journal of neuroinflammation (2020)
The data demonstrate a tissue engineered hydrogel platform can be used to investigate crosstalk between immune cells of the tumor microenvironment related to GBM progression. Such multi-dimensional models may provide valuable insight to inform therapeutic innovations to improve GBM treatment.
Keyphrases
- hyaluronic acid
- tissue engineering
- drug delivery
- induced apoptosis
- cell cycle arrest
- wound healing
- electronic health record
- inflammatory response
- cell migration
- high throughput
- neuropathic pain
- endoplasmic reticulum stress
- big data
- signaling pathway
- cell proliferation
- pi k akt
- spinal cord
- replacement therapy
- deep learning