Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2.

Ke LiuRongfeng ZouWenqiang CuiMeiqing LiXueying WangJunlin DongHongchun LiHongpei LiPeihui WangXiming ShaoWu SuH C Stephen ChanHongchang LiShuguang Yuan

Published in: ACS pharmacology & translational science (2020)

The outbreak of COVID-19 by the end of 2019 has posed serious health threats to humanity and jeopardized the global economy. However, no effective drugs are available to treat COVID-19 currently and there is a great demand to fight against it. Here, we combined computational screening and an efficient cellular pseudotyped virus system, confirming that clinical HDAC inhibitors can efficiently prevent SARS-CoV-2 and potentially be used to fight against COVID-19.

Keyphrases

sars cov
respiratory syndrome coronavirus
coronavirus disease
healthcare
public health
histone deacetylase
mental health
health information