Chimeric provirus of bovine leukemia virus/SMAD family member 3 in cattle with enzootic bovine leukosis.

Naganori NaoTomohiro OkagawaNaomi NojiriSatoru KonnaiHonami ShimakuraMisono TominagaHazuka Yoshida-FurihataEri NishiyamaTakahiro MatsudairaNaoya MaekawaShiro MurataMasamichi MuramatsuKazuhiko OhashiMasumichi Saito

Published in: Archives of virology (2024)

Bovine leukemia virus (BLV) is a member of the family Retroviridae that causes enzootic bovine leukemia (EBL). However, the association between BLV infection and EBL development remains unclear. In this study, we identified a BLV/SMAD3 chimeric provirus within CC2D2A intron 30 in monoclonal expanded malignant cells from a cow with EBL. The chimeric provirus harbored a spliced SMAD3 sequence composed of exons 3-9, encoding the short isoform protein, and the BLV-SMAD3 chimeric transcript was detectable in cattle with EBL. This is the first report of a BLV chimeric provirus that might be involved in EBL tumorigenesis.

Keyphrases

cell therapy
epithelial mesenchymal transition
transforming growth factor
acute myeloid leukemia
bone marrow
stem cells
mesenchymal stem cells
rna seq
signaling pathway
small molecule
protein protein