Enantiomer-Specific Cardiovascular Effects of the Ketone Body 3-Hydroxybutyrate.
Nigopan GopalasingamNiels MoeslundKristian Hylleberg ChristensenKristoffer Berg HansenJacob Marthinsen SeefeldtCasper HomiliusErik Nguyen NielsenMie Ringgaard DollerupAage Kristian Olsen AlstrupMogens JohannsenDonna M B BoedtkjerNiels MøllerHans EiskjærLars Christian GormsenBent Roni Ranghøj NielsenHenrik WiggersPublished in: Journal of the American Heart Association (2024)
3-OHB increased CO by reducing afterload. L-3-OHB exerted a stronger hemodynamic response than D-3-OHB due to higher circulating 3-OHB levels. There was a dissocitation between the myocardial metabolism and hemodynamic effects of the enantiomers, highlighting L-3-OHB as a potent cardiovascular agent with strong hemodynamic effects.