Preliminary Evaluation of a Novel Fetal Guinea Pig Myelomeningocele Model.

Sarah C StokesKaeli J YamashiroMelissa A VanoverLaura A GalganskiJordan E JacksonChristina M TheodorouChristopher D PivettiDiana Lee FarmerAijun Wang

Published in: BioMed research international (2021)

RA dosed at 60 mg/kg in guinea pigs between GA 12 and 15 did not result in MMC. Dunkin Hartley guinea pigs did not tolerate a hysterotomy near term in our surgical model. Further work is needed to determine if MMC can be induced in guinea pigs with alternate RA dosing.

Keyphrases

rheumatoid arthritis
disease activity
preterm infants
high glucose
diabetic rats
ankylosing spondylitis
systemic lupus erythematosus
oxidative stress
idiopathic pulmonary fibrosis
systemic sclerosis
stress induced