Islet neuropeptide Y receptors are functionally conserved and novel targets for the preservation of beta-cell mass.
Zara J FranklinAnastasia TsakmakiPatricia Fonseca PedroAileen J KingGuo Cai HuangSakeena AmjadShanta J PersaudGavin A BewickPublished in: Diabetes, obesity & metabolism (2017)
Taken together, our observations identify the islet Y receptors as promising targets for the preservation of beta-cell mass. As such, targeting these receptors could help to maintain beta-cell mass in both type 1 and type 2 diabetes, and may also be useful for improving islet transplantation outcomes.