The Principal Role of Several Members of HLA and IRF Genes in Prevention of Oral Mucositis After Chemoradiotherapy.
Babak ArjmandMahmood KhodadoostSomayeh Jahani SherafatMostafa Rezaei TaviraniNayebali AhmadiMaryam Hamzeloo MoghadamFarshad OkhovatianSina Rezaei TaviraniPublished in: Journal of lasers in medical sciences (2021)
Introduction: One of the chemoradiotherapy (CRT) side effects is oral mucositis (OM). Since photobiomodulation therapy (PBMT) is a public method for the repair process, in the present study the mechanism of PBMT in the prevention of OM is investigated via the bioinformatics approach. Methods: Six validated and significant differentially expressed genes (DEGs) associated with the prevention of OM in head and neck cancer (HNC) patients who had experienced CRT were extracted from the literature. After adding 50 neighbors from STRING, the network was constructed and analyzed. The results of the action map and network analysis were compared and discussed. Results: HLA gene family were identified as central nodes of the analyzed network. Based on action map finding, activation is prominent action and IRF9 was the potent activator. The role of the IRF gene family was highlighted by action map analysis. Conclusion: Regulation of the immune system by HLA and IRF genes family is a crucial factor in the prevention of OM in the studied patients.
Keyphrases
- network analysis
- dendritic cells
- end stage renal disease
- genome wide
- healthcare
- rectal cancer
- locally advanced
- ejection fraction
- systematic review
- radiation induced
- newly diagnosed
- chronic kidney disease
- bioinformatics analysis
- genome wide identification
- high density
- peritoneal dialysis
- squamous cell carcinoma
- dna methylation
- radiation therapy
- mental health
- cardiac resynchronization therapy
- patient reported outcomes
- high resolution
- emergency department
- genome wide analysis
- transcription factor
- chemotherapy induced
- patient reported
- cell therapy