Cell-free DNA profiling in retinoblastoma patients with advanced intraocular disease: An MSKCC experience.

Prachi Kothari Francesco Marass Julie L Yang Caitlin M StewartDennis StephensJuber PatelMaysun HasanXiaohong JingFanli MengJeanette EnriquezKety HubermanAgnes VialeJasmine H FrancisMichael F BergerNeerav ShuklaDavid H AbramsonIra J Dunkel Dana Wai Yi Tsui

Published in: Cancer medicine (2020)

Plasma cfDNA can detect somatic RB1 mutations in patients with unilateral retinoblastoma. Since intraocular biopsies are avoided in these patients because of concern about spreading tumor, cfDNA can potentially offer a noninvasive platform to guide clinical decisions about treatment, follow-up schemes, and risk of metastasis.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
patient reported outcomes
cataract surgery
genome wide
ultrasound guided