Human papillomavirus 16E6/E7 activates autophagy via Atg9B and LAMP1 in cervical cancer cells.

Chen TingtingYang ShizhouZhang SongfaXu JunfenLu WeiguoCheng XiaodongXing Xie

Published in: Cancer medicine (2019)

Our findings verified that 16E6/E7 activated autophagy via accelerating autophagosome formation and degradation, and Atg9B and LAMP1 were involved in the process of 16E6/E7 modulating autophagy, suggesting that targeting autophagy may be a potential approach in cervical cancer therapeutics.

Keyphrases

endoplasmic reticulum stress
cell death
signaling pathway
induced apoptosis
oxidative stress
cell cycle arrest
small molecule
loop mediated isothermal amplification
risk assessment
pi k akt
human health