CD161 expression and regulation defines rapidly responding effector CD4+ T cells associated with improved survival in HPV16-associated tumors.
Chantal L DuurlandSaskia J A M SantegoetsZiena AbdulrahmanNikki M LoofGregor SturmTom H WesselinkRamon ArensSanne BoekestijnIlina EhsanMariette I E van PoelgeestFrancesca FinotelloHubert HacklZlatko TrajanoskiPeter Ten DijkeVeronique M BraudMarij J P WeltersSjoerd H Van der BurgPublished in: Journal for immunotherapy of cancer (2022)
High levels of CD4+CD161+ Tem are associated with improved survival and our data show that CD161 is dynamically regulated by cell intrinsic and extrinsic factors. CD161 expressing CD4+ T cells rapidly respond to suboptimal antigen stimulation suggesting that CD161, similar to SOX4, is involved in the amplification of TCR signals in CD4+ T cells.