Semen quality and testicular adrenal rest tumour development in 46,XY congenital adrenal hyperplasia: the importance of optimal hormonal replacement.

Julia RohayemLena Maria BäumerMichael ZitzmannSusanne Fricke-OttoKlaus MohnikeBettina GohlkeFelix ReschkeClaus JourdanHerman L MüllerDésirée DunstheimerJohannes WeigelNorbert JorchElke Müller-RossbergErwin LankesImke GätjenAnnette Richter-UnruhBerthold P HauffaSabine KlieschAniko KrumbholzJürgen Brämswig

Published in: European journal of endocrinology (2021)

TART development is favoured by inadequate long-term hormonal control in CAH. Reduced semen quality may be associated with large TART. Gonadotropin suppression by adrenal androgen excess during the latest spermatogenic cycle may contribute to impairment of spermatogenesis.

Keyphrases

polycystic ovary syndrome
quality improvement
type diabetes
adipose tissue
skeletal muscle
insulin resistance