Male awareness of prostate cancer risk remains poor in relatives of women with germline variants in DNA-repair genes.

Vittorio FasuloNicolòMaria BuffiGiuseppe ChiarelliGiovanni LughezzaniMonica ZuradelliCarla Barbara RipamontiMonica BarilePaolo BianchiAlessio BenettiMarco PaciottiAlessandro UleriPier Paolo AvolioAlberto SaitaRodolfo HurleFederica MauraLuca GermagnoliRosanna AsseltaGiulia SoldàPaolo CasaleMassimo Lazzeri

Published in: BJUI compass (2023)

All men tested positive for a DRG variants agreed to go under the surveillance scheme. However, only 31% of 'men at risk' (i.e., relative of a DRG variant carrier) expressed their willingness to be tested for the familial DRG variant. This observation strongly supports the urgent need to implement awareness of genetic risk for PCa within the male population.

Keyphrases

dna repair
prostate cancer
copy number
dna damage
public health
middle aged
gene expression
early onset
oxidative stress
transcription factor