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Solid solution polymorphs afford two highly soluble co-drug forms of tolbutamide and chlorpropamide.

Enrico SpolettiVivek VermaChiara CappuccinoMatteo Lusi
Published in: Chemical communications (Cambridge, England) (2023)
The search for solid solutions of class-two insulin secretagogues, tolbutamide and chlorpropamide, reveals a rare case of monotropic polymorphism for the mixed crystals. At any stoichiometry, two crystal forms are isolated that are kinetically stable at room temperature from a few months to over a year. Dissolution tests certify the solubility advantage of the solid solutions over the pure drugs as well as their physical mixture, suggesting a potential application as a highly soluble co-drug formulation.
Keyphrases
  • room temperature
  • rare case
  • ionic liquid
  • type diabetes
  • physical activity
  • drug induced
  • mental health
  • drug delivery
  • adverse drug
  • emergency department
  • metabolic syndrome
  • risk assessment
  • human health