Venetoclax Cooperates with Ionizing Radiation to Attenuate Diffuse Midline Glioma Tumor Growth.

Krishna MadhavanIlango BalakrishnanSenthilnath LakshmanachettyAngela PierceBridget SanfordSusan FosmireHanan B ElajailiFaye WalkerDong WangEva S NozikSiddhartha S MitraNathan A DahlRajeev Vibhakar Sujatha Venkataraman

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

This study shows that venetoclax impedes the antiapoptotic function of radiation-induced BCL2 in DMG, leading to increased apoptosis. Results from these preclinical studies demonstrate the potential use of the BCL2 inhibitor venetoclax combined with radiotherapy for pediatric DMG.

Keyphrases

radiation induced
chronic lymphocytic leukemia
radiation therapy
oxidative stress
early stage
endoplasmic reticulum stress
cell death
low grade
cell therapy
squamous cell carcinoma
risk assessment
bone marrow
mesenchymal stem cells
locally advanced
case control
climate change
childhood cancer