A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine.

Bonnie L WaltonRebecca Shattuck-BrandtCatherine A HamannVictoria W TungJuan M ColazoDavid D BrandKaren A HastyCraig L DuvallJonathan M Brunger

Published in: bioRxiv : the preprint server for biology (2024)

This work demonstrates proof-of-concept that the synNotch platform guides MSCs for spatially regulated, disease-dependent delivery of OA-relevant biologic drugs.

Keyphrases

rheumatoid arthritis
mesenchymal stem cells
high throughput
transcription factor
knee osteoarthritis
umbilical cord
binding protein
bone marrow
drug induced