A gene risk score using missense variants in SLCO1B1 is associated with earlier onset statin intolerance.

Margherita Bigossi Cyrielle Maroteau Adem Y DawedAlasdair TaylorSundararajan SrinivasanAlaa' Lufti Melhem Ewan R Pearson Roberto Pola Colin Neil Alexander Palmer Moneeza K Siddiqui

Published in: European heart journal. Cardiovascular pharmacotherapy (2023)

We provide evidence that a gene risk score based on four common SLCO1B1 variants provides an easily implemented genetic tool that is more reliable than the current recommended practice in estimating the risk and predicting early onset statin intolerance.

Keyphrases

copy number
early onset
genome wide
late onset
cardiovascular disease
coronary artery disease
dna methylation
healthcare
primary care
genome wide identification
intellectual disability
low density lipoprotein
quality improvement
gene expression
transcription factor
breast cancer risk