Association of Inflammation With Pronociceptive Brain Connections in Rheumatoid Arthritis Patients With Concomitant Fibromyalgia.
Chelsea M KaplanAndrew SchrepfEric IchescoTony LarkinSteven E HarteRichard E HarrisAlison D MurrayGordon D WaiterDaniel J ClauwNeil BasuPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2019)
We report the first neurobiologic evidence that FM in RA may be linked to peripheral inflammation via pronociceptive patterns of brain connectivity. In patients with such "bottom-up" pain centralization, concomitant symptoms may partially respond to antiinflammatory treatments.
Keyphrases
- resting state
- rheumatoid arthritis
- white matter
- functional connectivity
- oxidative stress
- disease activity
- chronic pain
- multiple sclerosis
- ankylosing spondylitis
- cerebral ischemia
- pain management
- neuropathic pain
- interstitial lung disease
- brain injury
- blood brain barrier
- spinal cord
- spinal cord injury
- systemic sclerosis