Cold autoimmune hemolytic anemia: a rare association with triple-positive breast cancer.
Abubakar TauseefMuhammad Sohaib AsgharMaryam ZafarIftekhar AhmedMustafa DawoodTooba ShaikhNarmin KhanTanveer AlamPublished in: Journal of community hospital internal medicine perspectives (2019)
A 45-year-old Asian woman was presented with fever, easy fatigability, shortness of breath, cervical and axillary lymphadenopathy and other signs and symptoms of anemia. After all the baseline work-up, the patient was investigated for Mono-coombs C3d levels, which were elevated, suggesting the diagnosis of Cold autoimmune hemolytic anemia (Cold AIHA). An Ultrasound-guided true-cut biopsy was done to determine the primary cause associated with it, which showed the presence of tumor cells arranged in cords and clusters. They have dark staining cells with mitotic activity, suggestive of breast carcinoma as an association of Cold AIHA. Estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) were sent, which came out to be positive. So, the patient was diagnosed with Cold AIHA in association with triple-positive breast cancer.
Keyphrases
- positive breast cancer
- estrogen receptor
- ultrasound guided
- epidermal growth factor receptor
- chronic kidney disease
- case report
- fine needle aspiration
- iron deficiency
- multiple sclerosis
- tyrosine kinase
- endothelial cells
- induced apoptosis
- advanced non small cell lung cancer
- squamous cell carcinoma
- mass spectrometry
- cell proliferation
- depressive symptoms
- cell cycle arrest
- drug induced
- oxidative stress
- radiation therapy
- physical activity
- sleep quality
- sentinel lymph node