Regioselective Synthesis of Benzofuranones and Benzofurans.
Xiaojie ZhangChristopher M BeaudryPublished in: The Journal of organic chemistry (2021)
Reaction of 3-hydroxy-2-pyrones with nitroalkenes bearing ester groups gives benzofuranones. The reaction allows regioselective preparation of the benzofuranones with programmable substitution at any position. Complex substitution patterns are readily created. The substituted benzofuranones can be converted to substituted benzofurans.